Alternative splicing of micro-exons creates multiple forms of the insect cell adhesion molecule fasciclin I
نویسندگان
چکیده
منابع مشابه
Alternative splicing of micro-exons creates multiple forms of the insect cell adhesion molecule fasciclin I.
Fasciclin I is a homophilic cell adhesion molecule in insects that is dynamically expressed on a subset of axon pathways in the embryonic nervous system, and on a variety of other cells and tissues during development. The fasciclin I protein consists of four homologous 150 amino acid domains. In this article, we describe the complete sequence of the Drosophila fasciclin I (fasI) gene. The gene ...
متن کاملExpression and structural studies of fasciclin I, an insect cell adhesion molecule.
Fasciclin I is a lipid-linked cell-surface glycoprotein that can act as a homophilic adhesion molecule in tissue culture cells. It is thought to be involved in growth cone guidance in the embryonic insect nervous system. To facilitate structure-function studies, we have generated Chinese hamster ovary (CHO) cell lines expressing high levels of cell surface grasshopper and Drosophila fasciclin I...
متن کاملDynamic expression of the cell adhesion molecule fasciclin I during embryonic development in Drosophila.
A number of different cell surface glycoproteins expressed in the central nervous system (CNS) have been identified in insects and shown to mediate cell adhesion in tissue culture systems. The fasciclin I protein is expressed on a subset of CNS axon pathways in both grasshopper and Drosophila. It consists of four homologous 150-amino acid domains which are unrelated to other sequences in the cu...
متن کاملAltered nerve terminal arborization and synaptic transmission in Drosophila mutants of cell adhesion molecule fasciclin I.
This work investigates the role of cell adhesion molecules in development of synaptic connections and functions through a genetic approach. Fasciclin I (Fas I) is an insect glycoprotein capable of mediating homophilic cell adhesion. It has been shown that Fas I is expressed in motor nerve axons and terminals that innervate larval body-wall muscles in Drosophila. Immunohistochemical analysis of ...
متن کاملDrosophila fasciclin I is a novel homophilic adhesion molecule that along with fasciclin III can mediate cell sorting
Fasciclin I is a membrane-associated glycoprotein that is regionally expressed on a subset of fasciculating axons during neuronal development in insects; it is expressed on apposing cell surfaces, suggesting a role in specific cell adhesion. In this paper we show that Drosophila fasciclin I is a novel homophilic cell adhesion molecule. When the nonadhesive Drosophila S2 cells are transfected wi...
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ژورنال
عنوان ژورنال: The Journal of Neuroscience
سال: 1992
ISSN: 0270-6474,1529-2401
DOI: 10.1523/jneurosci.12-03-00895.1992